Earlier in October of 2025, there was an event in South Africa dedicated to the late Dr. Jackie Stone, titled “Dr. Jackie Stone Memorial Lectures”, hosted and livestreamed by the South African Vaccine Injury Medical Legal Study Group (savims.org.za) where Professor Colleen Aldous and a few others presented in person. Because of the time difference, the timing of the event was at 3:00 a.m. in the South Texas time zone, so I sent them a prerecorded lecture. I heard there were some technical problems for the remote attendees, so I am not sure to what extent they were able to present my prerecorded lecture. However, their plan was to present the first part of the lecture focusing on Sackett’s definition of evidence-based medicine, which functions just fine as a standalone short presentation.
The keynote presentation by Professor Colleen Aldous was posted on a previous stack. If a recording of the rest of the event is made publicly available, then I will follow up with an update. In the meantime, you can find here my entire presentation dedicated to the memory of Dr. Jackie Stone. The complete lecture begins with a discussion of Sackett’s definition of evidence-based medicine, followed with my paper on the statistical analysis of patient case series, my initial involvement with preparing a support letter when Dr. Stone was threatened with imprisonment, a brief overview of her paper, followed by our 2025 papers on her ivermectin-based protocol. The rest of the presentation reviews some aspects of the argument of our 2025 papers, starting with the Bradford Hill criteria and focusing on our application of the Bradford Hill criteria to Dr. Stone’s protocol. We conclude the presentation with the observation that the entire analysis presented was not really necessary, in the first place, to justify Dr. Stone’s decision to treat her patients, as she did at the time of the pandemic emergency.
As the anonymous “ohbaby” substack author noted, Dr. Jackie Stone deserved a medal and national, if not international, recognition and honors for pioneering one of the most powerful treatment protocols against COVID-19. Unfortunately, instead of recognition, her achievements were rewarded with unrelenting persecution, as was done with many other doctors pioneering COVID-19 treatments. The ultimate targets are not the doctors, but the patients, all of us, including you and me, who may lose their lives one day when ethical doctors are forbidden from providing the treatments that actually work, that we need, and that we are willing to consent to.
The slides for the presentation are available for download here:
References
1. D.L. Sackett, W.M.C. Rosenberg, J.A. Muir Gray, R. Brian Haynes, W. Scott Richardson, “Evidence based medicine: what it is and what it isn’t“, BMJ 312 (1996), 71
2. E. Gkioulekas, P.A. McCullough, V. Zelenko: “Statistical analysis methods applied to early outpatient COVID-19 treatment case series data“, COVID 2(8) (2022), 1139-1182
3. J.C. Stone, P. Ndarukwa, D.E. Scheim, BM Dancis, J. Dancis, M.G.Gill, C. Aldous, “Changes in SpO2 on Room Air for 34 Severe COVID-19 Patients after Ivermectin-Based Combination Treatment: 62% Normalization within 24 Hours“, Biologics. 2022 2(3) (2022), 196-210.
4. E. Gkioulekas, P.A. McCullough, C. Aldous: “Critical appraisal of multi-drug therapy in the ambulatory management of patients with COVID-19 and hypoxemia. Part I. Evidence supporting the strength of association“, The Japanese Journal of Antibiotics 78(1) (2025), 2-34
5. E. Gkioulekas, P.A. McCullough, C. Aldous: “Critical appraisal of multi-drug therapy in the ambulatory management of patients with COVID-19 and hypoxemia. Part II: Causal inference using the Bradford Hill criteria“, The Japanese Journal of Antibiotics 78(1) (2025), 35-68
6. A.B. Hill. “The Environment and Disease: Association or Causation?“, Proc R Soc Med. 58(5) (1965), 295-300.
7. J. Howick, P. Glasziou, J.K. Aronson, “The evolution of evidence hierarchies: what can Bradford Hill’s ‘guidelines for causation’ contribute?“, Journal of the Royal Society of Medicine 102(5) (2009), 186-94
8. A.C. Ward, “The role of causal criteria in causal inferences: Bradford Hill’s ‘aspects of association‘”, Epidemiologic Perspectives & Innovations 6 (2009), 2
